THE SCIENCE

The scientific information

I AM Lean

Yacon Root
  1. Gonzales GF, Gonzales-Castañeda C, Gasco M A mixture of extracts from Peruvian plants (black maca and yacon) improves sperm count and reduced glycemia in mice with streptozotocin-induced diabetes . Toxicol Mech Methods. (2013)
  2. Genta S, et al Yacon syrup: beneficial effects on obesity and insulin resistance in humans . Clin Nutr. (2009)
  3. Hong SS, et al Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of lps-induced nitric oxide production . Chem Pharm Bull (Tokyo). (2008)
  4. Takenaka M, et al Caffeic acid derivatives in the roots of yacon (Smallanthus sonchifolius) . J Agric Food Chem. (2003)
  5. Simonovska B, et al Investigation of phenolic acids in yacon (Smallanthus sonchifolius) leaves and tubers . J Chromatogr A. (2003)
  6. Yan X, et al Extraction and identification of antioxidants in the roots of yacon (Smallanthus sonchifolius) . J Agric Food Chem. (1999)
  7. Campos D, et al Prebiotic effects of yacon (Smallanthus sonchifolius Poepp. & Endl), a source of fructooligosaccharides and phenolic compounds with antioxidant activity . Food Chem. (2012)
  8. Pedreschi R, et al Andean yacon root (Smallanthus sonchifolius Poepp. Endl) fructooligosaccharides as a potential novel source of prebiotics . J Agric Food Chem. (2003)
  9. Delzenne NM, Kok N Effects of fructans-type prebiotics on lipid metabolism . Am J Clin Nutr. (2001)
  10. Kok N, et al Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats . Br J Nutr. (1996)
  11. Wright RS, Anderson JW, Bridges SR , Propionate inhibits hepatocyte lipid synthesis . Proc Soc Exp Biol Med. (1990)
  12. Nishina PM, Freedland RA Effects of propionate on lipid biosynthesis in isolated rat hepatocytes . J Nutr. (1990)
  13. Girard J, Ferré P, Foufelle F Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes . Annu Rev Nutr. (1997)
  14. Delgado GT, et al Yacon (Smallanthus sonchifolius)-derived fructooligosaccharides improves the immune parameters in the mouse. Nutr Res. (2012)
  15. Geyer M, et al Effect of yacon (Smallanthus sonchifolius) on colonic transit time in healthy volunteers . Digestion. (2008)
Baobab
  1. E. De Caluwe, K. Halamova and P. Van Damme (2010). Adansonia digitata L. – A review of traditional uses, phytochemistry and pharmacology. Afrika Fous, 23(1), 11-51.
  2. S. Vertuani et al (2002). Antioxidant capacity of Adansonia digitata fruit pulp and leaves. Acta Phytotherapeutica. 5(2).
  3. S. Coe et al (2013). The polyphenol-rich baobab fruit (Adansonia digitata L.) reduces starch digestion and glycemic response in humans. Nutrition Research, 33(11), 888-896.
  4. E. Adewusi and A. Afolayan (2010). A review of natural products with hepatoprotective activity. Journal of Medicinal Plants Research, 4(13), 1318-1334.
  5. A. Al-Qarawi, M. Al-Damegh and S. El-Mougy (2003). Hepatoprotective Influence of Adansonia digitata Pulp. Journal of Herbs, Spices & Medicinal Plants, 10, 3.
  6. M. Didibe et al (1996). Baobab-homegrown vitamin C for Africa. Agrofor. Today 8: 13-15.
  7. M. Osman (2004). Chemical and Nutrient Analysis of Baobab (Adansonia digitata): Fruit and Seed Protein Solubility. Plant Foods for Human Nutrition, 59, 29-33.
Maca
  1. Stone M, et al A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen . J Ethnopharmacol. (2009)
  2. Zenico T, et al Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial . Andrologia. (2009)
  3. Dording CM, et al A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction . CNS Neurosci Ther. (2008)
  4. Brooks NA, et al Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content . Menopause. (2008)
  5. Rubio J, et al Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice . Food Chem Toxicol. (2007)
  6. Rubio J, et al Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice . Evid Based Complement Alternat Med. (2011)
  7. Pino-Figueroa A, Nguyen D, Maher TJ Neuroprotective effects of Lepidium meyenii (Maca) . Ann N Y Acad Sci. (2010)
  8. Rubio J, et al Dose-response effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol . Toxicol Mech Methods. (2011)
  9. Valentová K, et al Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: in vivo safety assessment . Food Chem Toxicol. (2008)
  10. Vecera R, et al The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat . Plant Foods Hum Nutr. (2007)
  11. Gonzales GF, et al Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men . J Endocrinol. (2003)
  12. Rubio J, et al Lepidium meyenii (Maca) reversed the lead acetate induced — damage on reproductive function in male rats . Food Chem Toxicol. (2006)
  13. Gonzales GF, et al Effect of Black maca (Lepidium meyenii) on one spermatogenic cycle in rats . Andrologia. (2006)
  14. Valentová K, et al The in vitro biological activity of Lepidium meyenii extracts . Cell Biol Toxicol. (2006)
  15. Zhang Y, et al Effect of ethanol extract of Lepidium meyenii Walp. on osteoporosis in ovariectomized rat . J Ethnopharmacol. (2006)
  16. Gonzales C, et al Effects of different varieties of Maca (Lepidium meyenii) on bone structure in ovariectomized rats . Forsch Komplementmed. (2010)
  17. Gasco M, et al Dose-response effect of Red Maca (Lepidium meyenii) on benign prostatic hyperplasia induced by testosterone enanthate . Phytomedicine. (2007)
  18. Roehrborn CG, et al Effects of finasteride on serum testosterone and body mass index in men with benign prostatic hyperplasia . Urology. (2003)
  19. Cárdenas-Valencia I, et al Tropaeolum tuberosum (Mashua) reduces testicular function: effect of different treatment times . Andrologia. (2008)
  20. Gonzales GF, et al Antagonistic effect of Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice . Andrologia. (2008)
  21. Gonzales C, et al Effect of red maca (Lepidium meyenii) on prostate zinc levels in rats with testosterone-induced prostatic hyperplasia . Andrologia. (2012)
  22. Yucra S, et al Effect of different fractions from hydroalcoholic extract of Black Maca (Lepidium meyenii) on testicular function in adult male rats . Fertil Steril. (2008)
  23. Shin BC, et al Maca (L. meyenii) for improving sexual function: a systematic review . BMC Complement Altern Med. (2010)
  24. Ruiz-Luna AC, et al Lepidium meyenii (Maca) increases litter size in normal adult female mice . Reprod Biol Endocrinol. (2005)
Matcha
  1. Mason R (2001). 200 mg of Zen — L-theanine boosts alpha waves, promotes alert relaxation. Alternative Complementary Therapies, 7, 91-95
  2. Kamath A, Wang L, Das H et al. (2003). Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. Proceedings of the National Academy of Sciences USA, 100(10), 6009-14
  3. Juneja LR, Chu DC, Okubo T, et al. (1999). L-theanine — a unique amino acid of green tea and its relaxation effect in humans. Trends in Food Science & Technology, 10(6-7), 199-204
  4. Du Rand EE (2009). Identification of digallated and methylated catechins using UPLC/MS/MS and development of a rapid analysis method for theanine in tea [Camellia sinensis (L.) O. Kuntze) utilizing evaporative light scattering detection. University of Pretoria
  5. Yamada T, Terashima T, Honma H, et al (2008). Effects of Theanine, a Unique Amino Acid in Tea Leaves, on Memory in a Rat Behavioral Test. Bioscience, Biotechnology, and Biochemistry, 72(5), 1356-1359
  6. Kim T, Kee YK, Park SG, et al. (2009). L-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kB pathwaysFree Radical Biology and Medicine. Free Radical Biology and Medicine, 47(11), 1601-1610
  7. Matsuzaki T, Hara Y (1987). Antioxidative activity of tea leaf catechins. Journal of the Agricultural Chemical Society of Japan, 59(2), 129-134
Moringa
  1. Jaiswal D, et al Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats . J Ethnopharmacol. (2009)
  2. Rufai S, et al Genetic Dissection of New Genotypes of Drumstick Tree (Moringa oleifera Lam.) Using Random Amplified Polymorphic DNA Marker . Biomed Res Int. (2013)
  3. Shih MC, et al Effect of Different Parts (Leaf, Stem and Stalk) and Seasons (Summer and Winter) on the Chemical Compositions and Antioxidant Activity of Moringa oleifera . Int J Mol Sci. (2011)
  4. Maroyi A Use of weeds as traditional vegetables in Shurugwi District, Zimbabwe . J Ethnobiol Ethnomed. (2013)
  5. Abe R, Ohtani K An ethnobotanical study of medicinal plants and traditional therapies on Batan Island, the Philippines . J Ethnopharmacol. (2013)
  6. Bakre AG, Aderibigbe AO, Ademowo OG Studies on neuropharmacological profile of ethanol extract of Moringa oleifera leaves in mice . J Ethnopharmacol. (2013)
  7. Luqman S, et al Experimental Assessment of Moringa oleifera Leaf and Fruit for Its Antistress, Antioxidant, and Scavenging Potential Using In Vitro and In Vivo Assays . Evid Based Complement Alternat Med. (2012)
  8. Lockett CT, Calvert CC, Grivetti LE Energy and micronutrient composition of dietary and medicinal wild plants consumed during drought. Study of rural Fulani, northeastern Nigeria . Int J Food Sci Nutr. (2000)
  9. Bijina B, et al Protease inhibitor from Moringa oleifera with potential for use as therapeutic drug and as seafood preservative . Saudi J Biol Sci. (2011)
  10. Thurber MD, Fahey JW Adoption of Moringa oleifera to combat under-nutrition viewed through the lens of the “Diffusion of innovations” theory . Ecol Food Nutr. (2009)
  11. Prabhu K, et al Larvicidal and repellent potential of Moringa oleifera against malarial vector, Anopheles stephensi Liston (Insecta: Diptera: Culicidae) . Asian Pac J Trop Biomed. (2011)
Maqui
  1. Carlos L. Cespedes, Mohammed El-Hafidi, Natalia Pavon, and Julio Alarcon (2008). Antioxidant and cardioprotective activities of phenolic extracts from fruits of Chilean blackberry Aristotelia chilensis (Elaeocarpaceae), Maqui. Food Chemistry, 107(2), 820-829.
  2. Soledad Miranda-Rottmann et al (2002). Juice and Phenolic Fractions of the Berry Aristotelia chilensis Inhibit LDL Oxidation in Vitro and Protect Human Endothelial Cells against Oxidative Stress. J. Agric. Food Chem., 50(26), 7542-7547.
  3. Maria Teresa Escribano-Bailon et al (2006). Anthocyanins in berries of Maqui [Aristotelia chilensis (Mol.) Stuntz]. Phytochemical Analysis, 17(1), 8-14.
  4. Leonel E. Rojo et al (2012). In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis). Food Chemistry, 131(2), 387-396.
  5. P. Pacheco et al (1993). Antiviral activity of chilean medicinal plant extracts. Phytotherapy Research, 7(6), 415-418
  6. Basu A, Rhone M, Lyons TJ. “Berries: emerging impact on cardiovascular health.” Nutr Rev. 2010 Mar;68(3):168-77.
  7. Escribano-Bailón MT, Alcalde-Eon C, Muñoz O, Rivas-Gonzalo JC, Santos-Buelga C. “Anthocyanins in berries of Maqui (Aristotelia chilensis (Mol.) Stuntz).” Phytochem Anal. 2006 Jan-Feb;17(1):8-14.
  8. Muñoz O, Christen P, Cretton S, Backhouse N, Torres V, Correa O, Costa E, Miranda H, Delporte C. “Chemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae.” J Pharm Pharmacol. 2011 Jun;63(6):849-59.
  9. Prior RL, Wu X, Gu L, Hager TJ, Hager A, Howard LR. “Whole berries versus berry anthocyanins: interactions with dietary fat levels in the C57BL/6J mouse model of obesity.” J Agric Food Chem. 2008 Feb 13;56(3):647-53.
  10. Rubilar M, Jara C, Poo Y, Acevedo F, Gutierrez C, Sineiro J, Shene C. “Extracts of Maqui ( Aristotelia chilensis ) and Murta ( Ugni molinae Turcz.): sources of antioxidant compounds and α-Glucosidase/α-Amylase inhibitors.” J Agric Food Chem. 2011 Mar 9;59(5):1630-7.
Maitake
  1. Deng G, Lin H, Seidman A, et al. (September 2009). “A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects”. Journal of Cancer Research and Clinical Oncology 135 (9): 1215–21.
  2. Kodama N, Komuta K, Nanba H (2003). “Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients”. Journal of Medicinal Food 6 (4): 371–7.
  3. Kodama N, Komuta K, Sakai N, Nanba H (December 2002). “Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells”. Biological & Pharmaceutical Bulletin 25 (12): 1647–50.
  4. Kodama N, Asakawa A, Inui A, Masuda Y, Nanba H (March 2005). “Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa”. Oncology Reports 13 (3): 497–502.
  5. Kodama N, Murata Y, Nanba H (2004). “Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice”. Journal of Medicinal Food 7 (2): 141–5.
  6. Ulbricht C, Weissner W, Basch E, Giese N, Hammerness P, Rusie-Seamon E, Varghese M, Woods J. (2009). “Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration”. Journal of the Society for Integrative Oncology 7 (2): 66–72. PMID 19476741.
  7. Matsuur H, Asakawa C, Kurimoto M, Mizutani J (July 2002). “Alpha-glucosidase inhibitor from the seeds of balsam pear (Momordica charantia) and the fruit bodies of Grifola frondosa”. Bioscience, Biotechnology, and Biochemistry 66 (7): 1576–8.
  8. Zhang Y, Mills GL, Nair MG (December 2002). “Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa”. Journal of Agricultural and Food Chemistry 50 (26): 7581–5.
  9. Lee JS, Park BC, Ko YJ, et al. (December 2008). “Grifola frondosa (maitake mushroom) water extract inhibits vascular endothelial growth factor-induced angiogenesis through inhibition of reactive oxygen species and extracellular signal-regulated kinase phosphorylation”. Journal of Medicinal Food 11 (4): 643–51.
Triphala
  1. Jagetia, GC; Baliga, MS; Malagi, KJ; Sethukumar Kamath, M (Mar 2002). “The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to gamma-radiation.”. Phytomedicine : international journal of phytotherapy and phytopharmacology 9 (2): 99–108.
  2. Mahesh R, Bhuvana S, Begum VM (August 2009). “Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats”. Cell Biochem. Funct. 27 (6): 358–63.
  3. Sandhya T, Lathika KM, Pandey BN, et al. (October 2006). “Protection against radiation oxidative damage in mice by Triphala”. Mutat. Res. 609 (1): 17–25.
  4. Srikumar R, Parthasarathy NJ, Manikandan S, Narayanan GS, Sheeladevi R (February 2006). “Effect of Triphala on oxidative stress and on cell-mediated immune response against noise stress in rats”. Mol. Cell. Biochem. 283 (1-2): 67–74.
  5. Phetkate, Pratya; Kummalue, Tanawan; U-pratya, Yaowalak; Kietinun, Somboon. “Significant Increase in Cytotoxic T Lymphocytes and Natural Killer Cells by Triphala: A Clinical Phase I Study”. Evidence-Based Complementary and Alternative Medicine 2012: 1–6.
  6. Gupta, SureshKumar; Kalaiselvan, V; Srivastava, Sushma; Agrawal, ShyamS; Saxena, Rohit. “Evaluation of anticataract potential of Triphala in selenite-induced cataract: In vitro and in vivo studies”. Journal of Ayurveda and Integrative Medicine 1 (4): 280.
  7. Lu, Kai; Chakraborty, Debanjan; Sarkar, Chandrani; Lu, Tingting; Xie, Zhiliang; Liu, Zongfa; Basu, Sujit (24 August 2012). “Triphala and Its Active Constituent Chebulinic Acid Are Natural Inhibitors of Vascular Endothelial Growth Factor-A Mediated Angiogenesis”. PLOS one 7 (8): 7.
  8. Juss SS. Triphala – the wonder drug. Indian Med Gaz 1997;131:94-6.
Panax Ginseng
  1. Yun TK Brief introduction of Panax ginseng C.A. Meyer . J Korean Med Sci. (2001)
  2. Jia L, Zhao Y Current evaluation of the millennium phytomedicine–ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations. Curr Med Chem. (2009)
  3. Nag SA, et al Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action. Front Pharmacol. (2012)
  4. Liu CX, Xiao PG Recent advances on ginseng research in China. J Ethnopharmacol. (1992)
  5. Ahn JY, et al The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals. Eur J Immunol. (2006)
  6. Wan D, et al Structural characterization and immunological activities of the water-soluble oligosaccharides isolated from the Panax ginseng roots. Planta. (2012)
  7. Sun L, et al Structural characterization and immunostimulatory activity of a novel linear α-(1 6)-D-glucan isolated from Panax ginseng C. A. Meyer . Glycoconj J. (2012)
  8. Li C, et al Purification, characterization and anticancer activity of a polysaccharide from Panax ginseng. Int J Biol Macromol. (2012)
  9. Park S, Shin WS, Ho J Fructus panax ginseng extract promotes hair regeneration in C57BL/6 mice . J Ethnopharmacol. (2011)
  10. Chang YS, et al Panax ginseng: a role in cancer therapy. Integr Cancer Ther. (2003)
  11. Jung HJ, et al Enhancement of anti-inflammatory and antinociceptive actions of red ginseng extract by fermentation . J Pharm Pharmacol. (2012)
  12. Murata K, et al Effects of ginseng rhizome and ginsenoside Ro on testosterone 5α-reductase and hair re-growth in testosterone-treated mice . Phytother Res. (2012)
  13. Wang J, et al Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer. J Ethnopharmacol. (2010)
  14. Gaffney BT, Hügel HM, Rich PA The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes. Life Sci. (2001)
  15. Fujimoto K, et al Attenuation of anorexia induced by heat or surgery during sustained administration of ginsenoside Rg1 into rat third ventricle. Psychopharmacology (Berl). (1989)
  16. Karu N, Reifen R, Kerem Z Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor . J Agric Food Chem. (2007)
  17. Kang M, et al Ginsenoside Rg1 modulates ingestive behavior and thermal response induced by interleukin-1 beta in rats. Physiol Behav. (1995)
  18. Kim JH, et al Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat. J Pharmacol Sci. (2005)
  19. Attele AS, et al Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes. (2002)
  20. Etou H, et al Ginsenoside-Rb1 as a suppressor in central modulation of feeding in the rat . Nihon Yakurigaku Zasshi. (1988)
  21. Kim JH, et al Comparison of the antiobesity effects of the protopanaxadiol- and protopanaxatriol-type saponins of red ginseng . Phytother Res. (2009)
  22. Reay JL, Scholey AB, Kennedy DO Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults . Hum Psychopharmacol. (2010)
  23. Reay JL, Kennedy DO, Scholey AB Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity . J Psychopharmacol. (2005)
  24. Wang J, et al Antidepressant-like effects of the active acidic polysaccharide portion of ginseng in mice . J Ethnopharmacol. (2010)
  25. Dang H, et al Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression . Prog Neuropsychopharmacol Biol Psychiatry. (2009)
  26. Kim NH, et al Antidepressant-like effect of altered Korean red ginseng in mice . Behav Med. (2011)
  27. Kim Y, et al Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) gene expression in immobilization-stressed rats and PC12 cells . Nutr Res Pract. (2010)
  28. Liu L, et al , Ginsenoside Rb1 improves spatial learning and memory by regulation of cell genesis in the hippocampal subregions of rats . Brain Res. (2011)
  29. Petkov VD, et al Memory effects of standardized extracts of Panax ginseng (G115), Ginkgo biloba (GK 501) and their combination Gincosan (PHL-00701) . Planta Med. (1993)
  30. Attele AS, Wu JA, Yuan CS Ginseng pharmacology: multiple constituents and multiple actions . Biochem Pharmacol. (1999)
  31. Tian J, et al Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats . Neurosci Lett. (2005)
  32. Lee NH, Son CG Systematic review of randomized controlled trials evaluating the efficacy and safety of ginseng . J Acupunct Meridian Stud. (2011)
  33. Ellis JM, Reddy P Effects of Panax ginseng on quality of life . Ann Pharmacother. (2002)
  34. Sotaniemi EA, Haapakoski E, Rautio A Ginseng therapy in non-insulin-dependent diabetic patients . Diabetes Care. (1995)
  35. Wiklund IK, et al Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Swedish Alternative Medicine Group . Int J Clin Pharmacol Res. (1999)
Kelp

 

  • Dutot M, et al Antioxidant, anti-inflammatory, and anti-senescence activities of a phlorotannin-rich natural extract from brown seaweed Ascophyllum nodosum . Appl Biochem Biotechnol. (2012)
  • Zhang J, et al Antidiabetic properties of polysaccharide- and polyphenolic-enriched fractions from the brown seaweed Ascophyllum nodosum . Can J Physiol Pharmacol. (2007)
  • Cumashi A, et al A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds . Glycobiology. (2007)
  • Audibert L, et al Phenolic compounds in the brown seaweed Ascophyllum nodosum: distribution and radical-scavenging activities. Phytochem Anal. (2010)
  • Apostolidis E, Lee CM In vitro potential of Ascophyllum nodosum phenolic antioxidant-mediated alpha-glucosidase and alpha-amylase inhibition . J Food Sci. (2010)
  • Hall AC, et al Ascophyllum nodosum enriched bread reduces subsequent energy intake with no effect on post-prandial glucose and cholesterol in healthy, overweight males. A pilot study. Appetite. (2012)
  • Terpend K, et al Effects of ID-alG™ on weight management and body fat mass in high-fat-fed rats . Phytother Res. (2012)
  • Paradis ME, Couture P, Lamarche B A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women . Appl Physiol Nutr Metab. (2011)
  • Nakano K, et al Immunostimulatory activities of the sulfated polysaccharide ascophyllan from Ascophyllum nodosum in in vivo and in vitro systems . Biosci Biotechnol Biochem. (2012)
  • O’Sullivan AM, et al Assessment of the ability of seaweed extracts to protect against hydrogen peroxide and tert-butyl hydroperoxide induced cellular damage in Caco-2 cells . Food Chem. (2012)

 

I AM Beautiful

Pea Protein
  1. FDA-approved
  2. Nicolas Babault, Christos Païzis, Gaëlle Deley, Laetitia Guérin-Deremaux, Marie-Hélène Saniez, Catherine Lefranc-Millot and François A Allaert, Pea proteins oral supplementation promotes muscle thickness gains during resistance training: a double-blind, randomized, Placebo-controlled clinical trial vs. Whey protein, Journal of the International Society of Sports Nutrition 2015, 12:3
  3. Chentouf Aouatif, Ph. Looten, M. V. S. Parvathi, S. Raja Ganesh, and V. Paranthaman, Genotoxicological Evaluation of NUTRALYS Pea Protein Isolate, ISRN Toxicology, Volume 2013 (2013), Article ID 817353
Rosehip
  1. europepmc.org
  2. actahort.org
  3. Ziegler SJ (1986). “Fast and Selective Assay of l-Ascorbic Acid in Rose Hips by RP-HPLC Coupled with Electrochemical and/or Spectrophotometric Detection”. Planta Medica 52 (5): 383–7.
  4. Jacoby FC; Wokes F (1944). “Carotene and lycopene in rose hips and other fruit”. Biochem J 38 (3): 279–82. PMC 1258081.
  5. Horváth, G; Molnár, P; Radó-Turcsi, E; Deli, J; Kawase, M; Satoh, K; Tanaka, T; Tani, S; Sakagami, H; Gyémánt, N; Molnár, J (2012). “Carotenoid composition and in vitro pharmacological activity of rose hips” (PDF). Acta Biochimica Polonica 59 (1): 129–32.
Lucama
  1. Rojo LE, Villano CM, Joseph G, Schmidt B, Shulsev V, Shuman JL, Lila MA, Raskin I. Wound-healing properties of nut oil from Pouteria lucuma. Journal of Cosmetic Dermatology. 2010 September;9(3):185-95. doi: 10.1111/j/1473-2165.2010.00509.x.
  2. Pinto Mda S, Ranilla LG, Apostolidis E, Lajolo FM, Genovese MI, Shetty K. Evaluation of antihyperglycemia and antihypertension potential of native Peruvian fruits using in vitro models. Journal of Medicinal Food. 2009 April;12(2):276-91. doi: 10.1089/jmf.2008.0113.
Camu Camu
  1. Lucile T Abe, Franco M Lajolo and Maria Ines Genovese (2012). Potential dietary sources of ellagic acid and other antioxidants among fruits consumed in Brazil: Jabuticaba (Myrciaria jaboticaba (Vell.) Berg). Journal of the Science of Food and Agriculture, Malden, 92(8), suppl. 1, Part 2, p. 1679-1687.
  2. Akter, M.S. et al. (2011), Nutritional compositions and health promoting phytochemicals of camu-camu (myrciaria dubia) fruit: A review, Food Research International, 44(7), 1728-1732.
  3. USDA’s Nutrient Database for Standard Reference.
  4. C. Azevedo-Meleiro and D. Rodriguez-Amaya (2004). Confirmation of the identity of the carotenoids of tropical fruits by HPLC-DAD and HPLC-MS. Journal of Food Composition and Analysis, 17, 385-396.
  5. T. Inoue et al (2008). Tropical fruit camu-camu (Myrciaria dubia) has anti-oxidative and anti-inflammatory properties. Journal of Cardiology, 52(2), 127-132.
Goji Berry
  1. Isabelle, M.; Lee, B.L.; Lim, M.T.; Koh, W.-P.; Huang, D.; Ong, C.N. (2010). “Antioxidant activity and profiles of common vegetables in Singapore”. Food Chemistry 120 (4): 993–1003.
  2. Dong, J.; Lu, D.; Wang, Y. (2009). “Analysis of flavonoids from leaves of cultivated Lycium barbarum L.”. Plant Foods for Human Nutrition 64 (3): 199–204.
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Acai
  1. Shin DY, Lee WS, Lu JN, et al. Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK. Int J Oncol. 2009 Dec;35(6):1499-504.
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Beetroot
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Matcha
  1. Mason R (2001). 200 mg of Zen — L-theanine boosts alpha waves, promotes alert relaxation. Alternative Complementary Therapies, 7, 91-95
  2. Kamath A, Wang L, Das H et al. (2003). Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. Proceedings of the National Academy of Sciences USA, 100(10), 6009-14
  3. Juneja LR, Chu DC, Okubo T, et al. (1999). L-theanine — a unique amino acid of green tea and its relaxation effect in humans. Trends in Food Science & Technology, 10(6-7), 199-204
  4. Du Rand EE (2009). Identification of digallated and methylated catechins using UPLC/MS/MS and development of a rapid analysis method for theanine in tea [Camellia sinensis (L.) O. Kuntze) utilizing evaporative light scattering detection. University of Pretoria
  5. Yamada T, Terashima T, Honma H, et al (2008). Effects of Theanine, a Unique Amino Acid in Tea Leaves, on Memory in a Rat Behavioral Test. Bioscience, Biotechnology, and Biochemistry, 72(5), 1356-1359
  6. Kim T, Kee YK, Park SG, et al. (2009). L-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kB pathwaysFree Radical Biology and Medicine. Free Radical Biology and Medicine, 47(11), 1601-1610
  7. Matsuzaki T, Hara Y (1987). Antioxidative activity of tea leaf catechins. Journal of the Agricultural Chemical Society of Japan, 59(2), 129-134
Moringa
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Sea Buckthorn
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  10. Saggu S, Kumar R Effect of seabuckthorn leaf extracts on circulating energy fuels, lipid peroxidation and antioxidant parameters in rats during exposure to cold, hypoxia and restraint (C-H-R) stress and post stress recovery . Phytomedicine. (2008)
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Schisandra
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  4. Guo LY. Hung TM. Bae KH. Shin EM. Zhou HY. Hong YN. Kang SS. Kim HP. Kim YS.,”Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill.” European Journal of Pharmacology. 591(1-3):293-9, 2008 Sep 4.
  5. Xu XM, Li L, Chen M., “Studies on the chemical constituents of Schisandra pubescens”. Zhong Yao Cai. 2009 Sep;32(9):1399-401.
Shilajit
  1. Agarwal SP, Khanna R, Karmarkar R, Anwer MK, Khar RK. Shilajit: a review. Phytother Res. 2007 May;21(5):401-5.
  2. Pal D, Bhattacharya S. Pilot Study on the Improvement of Human Performance with ReVitalETTM as Energy Booster: Part-IV. 2006. Data on file. Natreon, Inc.
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  4. Visser SA. Effect of humic substances on mitochondrial respiration and oxidative phosphorylation. Sci Total Environ. 1987 Apr;62:347-54.
  5. Piotrowska D, Dlugosz A, Witkiewicz K, Pajak J. The research on antioxidative properties of TOLPA Peat Preparation and its fractions. Acta Pol Pharm. 2000 Nov;57 Suppl:127-9.
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I AM Energised

Mesquite
  1. Felker, Peter, Takeoka, Gary, Dao, Lan. “Pod Mesocarp Flour of North and South American Species of Leguminous Tree Prosopis (Mesquite): Composition and Food Applications.” Food Reviews International 29.1, 49-66, 2013.
  2. Capparelli, Aylen, and Verónica Lema. “Recognition of Post-harvest Processing of Algarrobo (Prosopis Spp.) as Food from Two Sites of Northwestern Argentina: An Ethnobotanical and Experimental Approach for Desiccated Macroremains – Springer.” Archaeological and Anthropological Sciences 3.1 (2011): 71-92.Springer Link. Springer-Verlag, 01 Mar. 2011
  3. Ortega-Nieblas, Magdalena, Luz Vázquez-Moreno, and María R. Robles-Burgueño. “Protein Quality and Antinutritional Factors of Wild Legume Seeds from the Sonoran Desert.” Journal of Agricultural and Food Chemistry 44.10 (1996): 3130-132.
Passion Fruit
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  2. Chau, C., Huang, Y., & Chang, F. (2005). Effects of fiber derived from passion fruit seed on the activities of ileum mucosal enzymes and colonic bacterial enzymes in hamsters. Journal of the Science of Food and Agriculture, 85(12), 2119-2124
  3. Sano S, Sugiyama K, Ito T, Katano Y, & Ishihata A. (2011). Identification of the strong vasorelaxing substance scirpusin B, a dimer of piceatannol, from passion fruit (Passiflora edulis) seeds. Journal of Agricultural and Food Chemistry, 59(11), 6209-6213.
Cacao
  1. Howell, L.L., Coffin, V.L., Spealman, R.D. Behavorial and physiological effects of xanthines in nonhuman primates (1997) Psychopharmacology, 129 (1), pp. 1–14.
  2. Usmani, Omar S.; Belvisi, Maria G.; Patel, Hema J.; Crispino, Natascia; Birrell Mark A.; Korbonits, Márta; Korbonits, Dezső; Barnes, Peter J. (November 17, 2004). “Theobromine inhibits sensory nerve activation and cough”. FASEB Journal 19 (2): 231–3.
  3. Teresa L. Dillinger, Patricia Barriga, Sylvia Escarcega, Martha Jimenez, Diana Salazar Lowe, Louis E. Grivetti, “Food of the Gods: Cure for Humanity? A Cultural History of the Medicinal and Ritual Use of Chocolate”, The Journal of Nutrition. November 28, 2010
  4. Francois-Pierre J. Martin, Serge Ressi, Emma Per-Trepat, Beate Kamlage, Sebastiano Collino, Edgar Leibold, Jurgen Kastler, Dietrich Rein, Laurent B. Fay, Sunil Kochhar, “Metabolic Effects of Dark Chocolate Consumption on Energy, Gut Microbiota, and Stress-Related Metabolism in Free-Living Subjects”, Journal of Proteome Research, October 7, 2009, 8 (12), pp 5568-5579
  5. Andrew B Scholey, Stephen J French, Penelope J Morris, David O Kennedy, Athea L Milne, Crystal F Haskell, “Consumption of coca flavanols results in acute improvements in mood and cognitive performance during sustained mental effort”. Journal of Psychopharmacology, October 2010, 24 (10)
Spirulina
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  2. Khan, Z; Bhadouria, P; Bisen, PS (October 2005). “Nutritional and therapeutic potential of Spirulina.”. Current pharmaceutical biotechnology 6 (5): 373–9. PMID 16248810.
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  4. Tokusoglu, O.; Unal, M.K. “Biomass Nutrient Profiles of Three Microalgae: Spirulina platensis, Chlorella vulgaris, and Isochrisis galbana”. Journal of Food Science 68 (4): 2003.
  5. Li, ZY; Guo, SY; Li, L; Cai, MY (February 2007). “Effects of electromagnetic field on the batch cultivation and nutritional composition of Spirulina platensis in an air-lift photobioreactor.”. Bioresource technology 98 (3): 700–5. PMID 16581244.
  6. Dey, S; Rathod, VK (January 2013). “Ultrasound assisted extraction of β-carotene from Spirulina platensis.”. Ultrasonics sonochemistry 20 (1): 271–6. PMID 22705076.
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  8. Salazar, M; Martínez, E; Madrigal, E; et al. (October 1998). “Subchronic toxicity study in mice fed Spirulina maxima”. Journal of Ethnopharmacology 62 (3): 235–41.
  9. Chamorro-Cevallos, G.; Barron, B.L.; Vasquez-Sanchez, J. (2008). Gershwin, M.E., ed. “Toxicologic Studies and Antitoxic Properties of Spirulina”. Spirulina in Human Nutrition and Health (CRC Press).
  10. Belay, Amha (2008). “Spirulina (Arthrospira): Production and Quality Assurance”. Spirulina in Human Nutrition and Health, CRC Press: 1–25.
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  13. Buono, S; Langellotti, AL; Martello, A; Rinna, F; Fogliano, V (August 2014). “Functional ingredients from microalgae.”. Food & function 5 (8): 1669–85. PMID 24957182.
  14. Siva Kiran RR, Madhu GM, Satyanarayana SV, Kalpana P, Bindiya P, Subba Rangaiah G. “Equilibrium and kinetic studies of lead biosorption by three Spirulina (Arthrospira) species in open raceway ponds.” Journal of Biochemical Technology Vol. 6, no. 1 (2015): 894-909.
Ashwagandha
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  5. Chandrasekhar K, Kapoor J, Anishetty S, A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults . Indian J Psychol Med. (2012)
  6. Modak M, et al, Indian herbs and herbal drugs used for the treatment of diabetes . J Clin Biochem Nutr. (2007)
  7. Choudhary MI, et al, Chlorinated and diepoxy withanolides from Withania somnifera and their cytotoxic effects against human lung cancer cell line . Phytochemistry. (2010)
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  9. Mishra LC, Singh BB, Dagenais S, Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review . Altern Med Rev. (2000)
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  11. Mulabagal V, et al, Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation . Phytother Res. (2009)
  12. Alam N, et al High catechin concentrations detected in Withania somnifera (ashwagandha) by high performance liquid chromatography analysis . BMC Complement Altern Med. (2011)
Maca
  1. Stone M, et al A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen . J Ethnopharmacol. (2009)
  2. Zenico T, et al Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial . Andrologia. (2009)
  3. Dording CM, et al A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction . CNS Neurosci Ther. (2008)
  4. Brooks NA, et al Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content . Menopause. (2008)
  5. Rubio J, et al Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice . Food Chem Toxicol. (2007)
  6. Rubio J, et al Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice . Evid Based Complement Alternat Med. (2011)
  7. Pino-Figueroa A, Nguyen D, Maher TJ Neuroprotective effects of Lepidium meyenii (Maca) . Ann N Y Acad Sci. (2010)
  8. Rubio J, et al Dose-response effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol . Toxicol Mech Methods. (2011)
  9. Valentová K, et al Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: in vivo safety assessment . Food Chem Toxicol. (2008)
  10. Vecera R, et al The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat . Plant Foods Hum Nutr. (2007)
  11. Gonzales GF, et al Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men . J Endocrinol. (2003)
  12. Rubio J, et al Lepidium meyenii (Maca) reversed the lead acetate induced — damage on reproductive function in male rats . Food Chem Toxicol. (2006)
  13. Gonzales GF, et al Effect of Black maca (Lepidium meyenii) on one spermatogenic cycle in rats . Andrologia. (2006)
  14. Valentová K, et al The in vitro biological activity of Lepidium meyenii extracts . Cell Biol Toxicol. (2006)
  15. Zhang Y, et al Effect of ethanol extract of Lepidium meyenii Walp. on osteoporosis in ovariectomized rat . J Ethnopharmacol. (2006)
  16. Gonzales C, et al Effects of different varieties of Maca (Lepidium meyenii) on bone structure in ovariectomized rats . Forsch Komplementmed. (2010)
  17. Gasco M, et al Dose-response effect of Red Maca (Lepidium meyenii) on benign prostatic hyperplasia induced by testosterone enanthate . Phytomedicine. (2007)
  18. Roehrborn CG, et al Effects of finasteride on serum testosterone and body mass index in men with benign prostatic hyperplasia . Urology. (2003)
  19. Cárdenas-Valencia I, et al Tropaeolum tuberosum (Mashua) reduces testicular function: effect of different treatment times . Andrologia. (2008)
  20. Gonzales GF, et al Antagonistic effect of Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice . Andrologia. (2008)
  21. Gonzales C, et al Effect of red maca (Lepidium meyenii) on prostate zinc levels in rats with testosterone-induced prostatic hyperplasia . Andrologia. (2012)
  22. Yucra S, et al Effect of different fractions from hydroalcoholic extract of Black Maca (Lepidium meyenii) on testicular function in adult male rats . Fertil Steril. (2008)
  23. Shin BC, et al Maca (L. meyenii) for improving sexual function: a systematic review . BMC Complement Altern Med. (2010)
  24. Ruiz-Luna AC, et al Lepidium meyenii (Maca) increases litter size in normal adult female mice . Reprod Biol Endocrinol. (2005)
Muira Puama
  1. Shamloul R, Natural aphrodisiacs., J Sex Med. (2010)
  2. Tang W, et al, Clerodane diterpenoids with NGF-potentiating activity from Ptychopetalum olacoides., J Nat Prod. (2008)
  3. Piato AL, et al, Antidepressant profile of Ptychopetalum olacoides Bentham (Marapuama) in mice . Phytother Res. (2009)
  4. Tang W, et al Eight new clerodane diterpenoids from the bark of Ptychopetalum olacoides . Nat Prod Commun. (2011)
  5. Tang W, et al Novel NGF-potentiating diterpenoids from a Brazilian medicinal plant, Ptychopetalum olacoides . Bioorg Med Chem Lett. (2009)
  6. Piato AL, et al Anti-stress effects of the “tonic” Ptychopetalum olacoides (Marapuama) in mice . Phytomedicine. (2010)
  7. Waynberg J, Brewer S, Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women., Adv Ther. (2000)
  8. Figueiró M, et al, The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse Alzheimer model . Phytomedicine. (2011)
  9. Figueiró M, et al Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama) . Phytomedicine. (2010)
  10. Siqueira IR, et al Ptychopetalum olacoides, a traditional Amazonian “nerve tonic”, possesses anticholinesterase activity . Pharmacol Biochem Behav. (2003)
  11. Siqueira IR, et al Antioxidant activities of Ptychopetalum olacoides (“muirapuama”) in mice brain . Phytomedicine. (2007)
  12. da Silva AL, et al MK801- and scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a “brain tonic” . Psychopharmacology (Berl). (2009)
  13. da Silva AL, et al Serotonin receptors contribute to the promnesic effects of P. olacoides (Marapuama) . Physiol Behav. (2008)
  14. da Silva AL, et al Promnesic effects of Ptychopetalum olacoides in aversive and non-aversive learning paradigms . J Ethnopharmacol. (2007)
  15. da Silva AL, et al Memory retrieval improvement by Ptychopetalum olacoides in young and aging mice . J Ethnopharmacol. (2004)
  16. Piato AL, et al Effects of Marapuama in the chronic mild stress model: further indication of antidepressant properties . J Ethnopharmacol. (2008)
  17. da Silva AL, et al Anxiogenic properties of Ptychopetalum olacoides Benth. (Marapuama) . Phytother Res. (2002)
Matcha
  1. Mason R (2001). 200 mg of Zen — L-theanine boosts alpha waves, promotes alert relaxation. Alternative Complementary Therapies, 7, 91-95
  2. Kamath A, Wang L, Das H et al. (2003). Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. Proceedings of the National Academy of Sciences USA, 100(10), 6009-14
  3. Juneja LR, Chu DC, Okubo T, et al. (1999). L-theanine — a unique amino acid of green tea and its relaxation effect in humans. Trends in Food Science & Technology, 10(6-7), 199-204
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